Primal Health Databank: Study
| Entry No: | 1116 |
| Title: | Caesarean delivery is associated with higher risk of overweight in the offspring: within-family analysis in the SUN cohort |
| Author(s): | MartÃn-Calvo N, et al. |
| Reference: | J Epidemiol Community Health. 2020 Jun;74(7):586-591. doi: 10.1136/jech-2019-213724. Epub 2020 Apr 24. |
| Place of Study: | Spain |
| Abstract: | Methods: Women in the 'Seguimiento Universidad de Navarra' cohort provided structured information regarding their pregnancy history and their children's health through online cross-sectional questionnaires. We calculated adjusted differences in BMI z-score and risk ratios (RR) for offspring's overweight/obesity associated with CD, with hierarchical models to account for correlations between siblings. We also performed a within-family analysis in 341 siblings who were discordant in delivery mode, using conditional multivariable logistic regression.
Results: Among the 2791 children analysed, those born by CD had higher average BMI z-scores (difference: 0.17; 95% CI 0.07 to 0.27) and higher risk of overweight/obesity (RR: 1.32, 95% CI 1.05 to 1.65) than children born vaginally. The association did not differ by maternal characteristics or offspring's age strata, and the results were consistent in sensitivity analyses. Furthermore, within-family analysis showed that children born by CD had 2.67-fold higher risk of overweight/obesity (95% CI 1.10 to 5.12) than their peers born vaginally.
Conclusion: Children born by CD have higher average BMI z-scores and higher risk of overweight/obesity than children born vaginally. The consistency of these findings across multiple approaches to address potential residual confounding likely suggests a true biological effect.
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| Keyword(s): | caesarean, cesarean, obesity, obesity in chilhood, Overweight |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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