Primal Health Databank: Study
| Entry No: | 1095 |
| Title: | Pubertal development after unintended intrauterine exposure to oral contraceptives: a nationwide cohort study |
| Author(s): | Ernst A, Lauridsen LL, et al |
| Reference: | Fertil Steril. 2019 Jul 13. pii: S0015-0282(19)30435-2. doi: 10.1016/j.fertnstert.2019.05.011. |
| Place of Study: | Denmark |
| Abstract: | Overall, 15,800 children (70%) born during 2000-2003 into the Danish National Birth Cohort were categorized according to maternal use of combined oral contraceptive pills or progestin-only pills reported around gestational week 17: no exposure (reference), exposure 4 months before conception, and exposure in early pregnancy. Children self-assessed pubertal status using Web-based questionnaires from 11 years and biannually throughout puberty.
In boys, intrauterine exposure to oral contraceptives showed a tendency toward slightly earlier mean age for voice break (months, -3.8; 95% confidence interval [CI] -6.5, -1.0) and first ejaculation (months, -2.9; 95% CI -5.9, 0.1) and a mean difference of -1.4 months (95% CI -3.3, 0.4) for overall pubertal timing. Girls with intrauterine exposure tended to have slightly earlier age at menarche (months, -1.9; 95% CI -4.0, 0.3) and Tanner breast stages and had a mean difference of -0.9 months (95% CI -2.7, 1.0) for overall pubertal timing. Exposure before conception was not associated with pubertal timing. Prepubertal body mass index did not play a mediating role.
CONCLUSION(S):
This study shows some evidence that intrauterine exposure to oral contraceptives might slightly affect pubertal timing. |
| Keyword(s): | contraception, puberty |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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