Primal Health Databank: Study
| Entry No: | 1082 |
| Title: | Air pollution and Autism in Denmark |
| Author(s): | Ritz B, Liew Z, et al |
| Reference: | Environ Epidemiol. 2018 Dec;2(4). pii: e028. doi: 10.1097/EE9.0000000000000028 |
| Place of Study: | Denmark |
| Abstract: | Previous autism spectrum disorder (ASD) and air pollution studies focused on pregnancy exposures, but another vulnerable period is immediate postnatally. Here, the authors examined early life exposures to air pollution from the pre- to the postnatal period and ASD/ASD subtypes in the Danish population.
With Danish registers, the authors conducted a nationwide case-control study of 15,387 children with ASD born 1989-2013 and 68,139 population controls matched by birth year and sex identified from the birth registry. They generated air dispersion model (AirGIS) estimates for NO2, SO2, PM2.5 and PM10 at mothers' home from 9 months before to 9 months after pregnancy and calculated odds ratios (OR) and 95% confidence intervals (CI), adjusting for parental age, neighborhood socio-economic indicators, and maternal smoking using conditional logistic regression.
In models that included all exposure periods, the authors estimated adjusted ORs for ASD per interquartile range (IQR) increase for 9 month after pregnancy with NO2 of 1.08 (95% CI: 1.01, 1.15) and with PM2.5 of 1.06 (95% CI: 1.01, 1.11); associations were smaller for PM10 (1.04; 95% CI: 1.00, 1.09) and strongest for SO2 (1.21; 95% CI: 1.13, 1.29). Also, associations for pollutants were stronger in more recent years (2000-2013) and in larger cities compared with provincial towns/rural counties. For particles and NO2, associations were only specific to autism and Asperger diagnoses.
These data suggest that air pollutant exposure in early infancy but not during pregnancy increases the risk of being diagnosed with autism and Asperger among children born in Denmark |
| Keyword(s): | air pollution, autism, autistic spectrum disorder |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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