Primal Health Databank: Study

Entry No:1081
Title:Maternal antibiotic use during pregnancy and childhood obesity at age 5 years.
Author(s):Heerman WJ, Boone-Heinonen J, et al
Reference:Int J Obes (Lond). 2019 Jan 22. doi: 10.1038/s41366-018-0316-6. [Epub ahead of print]
Place of Study:USA
Abstract:To evaluate the association of maternal antibiotic exposure during pregnancy on childhood BMI-z at 5 years, the authors conducted a retrospective cohort analysis. Using electronic health record data from seven health systems in PCORnet, a national distributed clinical research network, the authors included children with same-day height and weight measures who could be linked to mothers with vital measurements during pregnancy. The primary independent variable was maternal outpatient antibiotic prescriptions during pregnancy (any versus none). The authors examined dose response (number of antibiotic episodes), spectrum and class of antibiotics, and antibiotic episodes by trimester. The primary outcome was child age- and sex-specific BMI-z at age 5 years. The final sample was 53,320 mother-child pairs. During pregnancy, 29.9% of mothers received antibiotics. In adjusted models, maternal outpatient antibiotic prescriptions during pregnancy were not associated with child BMI-z at age 5 years (β = 0.00, 95% CI -0.03, 0.02). When evaluating timing during pregnancy, dose-response, spectrum and class of antibiotics, there were no associations of maternal antibiotics with child BMI-z at age 5 years. CONCLUSION: In this large observational cohort, provision of antibiotics during pregnancy was not associated with childhood BMI-z at 5 years.
Keyword(s):antibiotics, obesity, obesity in chilhood
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