Primal Health Databank: Study
| Entry No: | 1071 |
| Title: | Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial. |
| Author(s): | Vinding RK, Stokholm J, et al |
| Reference: | BMJ. 2018 Sep 4;362:k3312. doi: 10.1136/bmj.k3312. |
| Place of Study: | Denmark |
| Abstract: | The objective is to examine the effect of supplementation with n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) in pregnancy on anthropometry and body composition in offspring.
DESIGN:
Double blinded, randomised controlled trial.
SETTING:
Copenhagen Prospective Studies on Asthma in Childhood2010 cohort.
PARTICIPANTS:
736 pregnant women and their offspring.
INTERVENTION:
n-3 LCPUFA (fish oil) or control (olive oil) daily from pregnancy week 24 until one week after birth.
MAIN OUTCOME MEASURES:
Height/length, weight, head, and waist measurements and body composition from dual energy x ray absorptiometry (all pre-specified secondary endpoints of the n-3 LCPUFA trial; the primary outcome for the trial was persistent wheeze/asthma).
RESULTS:
The mean body mass index (BMI) z score was increased between age 0 and 6 years in the fish oil supplementation group compared with the control group (0.14 (95% confidence interval 0.04 to 0.23); P=0.006). At 6 years, supplementation was associated with a higher BMI z score (0.19 (0.06 to 0.32); P=0.004), a higher weight/height (3.48 (0.38 to 6.57) g/cm; P=0.03), and a larger waist circumference (0.6 (0.0 to 1.2) cm; P=0.04) but not a higher proportion of obese children, using International Obesity Task Force grades. The dual energy x ray absorptiometry scan at age 6 years showed a higher total mass (395.4 (86.6 to 704.3) g; P=0.01) in the supplementation versus the control group, explained by a higher lean mass (280.7 (98.9 to 462.4) g; P=0.002), a higher bone mineral content (10.3 (2.3 to 18.1) g; P=0.01), and a non-significantly higher fat mass (116.3 (-92.9 to 325.5) g; P=0.28), but no differences were seen in total body fat or lean mass percentage.
CONCLUSION:
Fish oil supplementation from the 24th week of pregnancy led to a higher BMI in the offspring from 0 to 6 years of age but not an increased risk of obesity at age 6. The body composition at age 6 years in children given fish oil supplementation was characterised by a proportional increase in lean, bone, and fat mass suggesting a general growth stimulating effect of n-3 LCPUFA. |
| Keyword(s): | BMI, body fat, body mass index, bone mineral content, fish, fish oil, obesity, obesity in chilhood |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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