Primal Health Databank: Study
| Entry No: | 1052 |
| Title: | In utero exposure to gestational diabetes and adiposity: does breastfeeding make a difference? |
| Author(s): | Li AM, et al |
| Reference: | Int J Obes (Lond). 2018 May 17. doi: 10.1038/s41366-018-0077-2. [Epub ahead of print] |
| Place of Study: | China |
| Abstract: | In the prospective Chinese birth cohort "Children of 1997" (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2- < 8 years) and adolescence (8-16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position. The authors also tested whether the associations differed by mode of infant feeding (always formula-fed, mixed, always breastfed) during the first three months of life.
In utero GDM exposure (7.5%) was associated with a lower BMI z-score during infancy (-0.13, 95% confidence interval (CI) -0.22, -0.05) but higher BMI z-scores during childhood (0.14, 95% CI 0.03, 0.25) and adolescence (0.25 95% CI 0.11, 0.38). Breastfeeding for the first three months did not modify the association of in utero GDM status with subsequent BMI (all p values for interaction >0.4).
CONCLUSIONS:
In utero GDM exposure was associated with greater adiposity during childhood and adolescence. |
| Keyword(s): | adiposity, BMI, gestational diabetes |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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