Primal Health Databank: Study
| Entry No: | 1034 |
| Title: | Influence of intergenerational in utero parental energy and nutrient restriction on offspring growth in rural Gambia. |
| Author(s): | et al |
| Reference: | FASEB J. 2017 Aug 4. pii: fj.201700017R. doi: 10.1096/fj.201700017R. [Epub ahead of print] |
| Place of Study: | Gambia |
| Abstract: | The authors investigated the association of parental exposure to energy and nutrient restriction in utero on their children's growth in rural Gambia. In a Gambian cohort with infants born between 1972 and 2011, the authors used multiple regression to test whether parental season of birth predicted offspring birth weight (n = 2097) or length (n = 1172), height-for-age z-score (HAZ), weight-for-height z-score (WHZ), and weight-for-age z-score (WAZ) at 2 yr of age (n = 923). They found that maternal exposure to seasonal energy restriction in utero was associated with reduced offspring birth length (crude:-4.2 mm, P = 0.005; adjusted: -4.0 mm, P = 0.02). In contrast, paternal birth season predicted offspring HAZ at 24 mo (crude: -0.21, P = 0.005; adjusted: -0.22, P = 0.004) but had no discernible impact at birth. These results indicate that periods of nutritional restriction in a parent's fetal life can have intergenerational consequences in human populations. Fetal growth appears to be under matriline influence, and postnatal growth appears to be under patriline intergenerational influences. |
| Keyword(s): | nutrition during pregnancy, nutrition in pregnancy, seasonality of birth, transgenerational |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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