Primal Health Databank: Study
| Entry No: | 1021 |
| Title: | Association of Perinatal Risk Factors with Autism Spectrum Disorder. |
| Author(s): | Getahun D, Fassett MJ, et al |
| Reference: | Am J Perinatol. 2017 Feb;34(3):295-304. doi: 10.1055/s-0036-1597624. Epub 2017 Jan 31. |
| Place of Study: | USA |
| Abstract: | Objective: To examine the association between exposures to perinatal factors and autism spectrum disorders (ASD). Study Design A retrospective cohort study of ASD among children born in Kaiser Permanente Southern California hospitals between 1991 and 2009 (n = 594,638). Medical records were used to determine exposure to perinatal (antepartum and intrapartum) complications. ASD was diagnosed using DSM-IV criteria. Multivariable Cox regression was used to estimate hazard ratios (HRs). Result Children with ASD were more likely to be exposed to perinatal complications (HR = 1.15, 95% confidence interval [CI]: 1.09-1.21) than neurotypical children. Children exposed to antepartum (HR = 1.22, 95% CI: 1.10-1.36) and intrapartum (HR = 1.10, 95% CI: 1.04-1.17) complications were at increased risk of ASD. The risk was even greater when both antepartum and intrapartum conditions were present (HR = 1.44, 95% CI: 1.26-1.63). Conclusion Exposure to antepartum or intrapartum complications increases the risk of ASD in the offspring. |
| Keyword(s): | antepartum complications, autism, autistic spectrum disorder, intrapartum complications |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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