Primal Health Databank: Study
| Entry No: | 1019 |
| Title: | Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births |
| Author(s): | Yip BH, Leonard H |
| Reference: | Int J Epidemiol. 2016 Dec 25. pii: dyw336. doi: 10.1093/ije/dyw336. [Epub ahead of print] |
| Place of Study: | multi-national |
| Abstract: | Using population-based registries of four Nordic countries and Western Australia, this study population included 4 987 390 singletons surviving their first year of life, which included 671 646 CS deliveries and 31 073 ASD (autistic spectrum disorder) children. The authors used logistic regression to estimate odds ratios (OR) and their 95% confidence intervals (CI) for CS, adjusted for gestational age, site, maternal age and birth year. Stratified analyses were conducted by both gestational age subgroups and by week of gestation. The authors compared emergency versus planned CS to investigate their potential difference in the risk of ASD.
Compared with vaginal delivery, the overall adjusted OR for ASD in CS delivery was 1.26 (95% CI 1.22-1.30). Stratified ORs were 1.25 (1.15-1.37), 1.16 (1.09-1.23), 1.34 (1.28-1.40) and 1.17 (1.04-1.30) for subgroups of gestational weeks 26-36, 37-38, 39-41 and 42-44, respectively. CS was significantly associated with risk of ASD for each week of gestation, from week 36 to 42, consistently across study sites (OR ranged 1.16-1.38). There was no statistically significant difference between emergency and planned CS in the risk of ASD.
CONCLUSION:
Across the five countries, emergency or planned CS is consistently associated with a modest increased risk of ASD from gestational weeks 36 to 42 when compared with vaginal delivery. |
| Keyword(s): | autism, autistic spectrum disorder, caesarean, cesarean |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search