Primal Health Databank: Study
| Entry No: | 1009 |
| Title: | Influence of fetal blood flow redistribution on fetal and childhood growth and fat distribution: the Generation R Study. |
| Author(s): | Gaillard R, et al |
| Reference: | BJOG. 2016 Mar 3. doi: 10.1111/1471-0528.13933. [Epub ahead of print] |
| Place of Study: | Netherlands |
| Abstract: | The authors examined the associations of fetal blood flow redistribution with birth outcomes, and repeatedly measured fetal and childhood growth and fat mass measures.
DESIGN:
Prospective cohort study.
SETTING:
Population-based.
POPULATION:
One thousand one hundred and ninety-five pregnant women and their children.
METHODS:
The authors measured umbilical and cerebral artery blood flow at a gestational age of 30.3 weeks (95% range, 28.5-32.6 weeks). A higher umbilical/cerebral (U/C) pulsatility index ratio is an indicator of preferential blood flow to the brain cerebral circulation at the expense of the lower body parts.
MAIN OUTCOME MEASURES:
Fetal and childhood growth were repeatedly measured from the third trimester until childhood. We measured the total body fat mass, lean fat mass and android/gynoid fat mass ratio by dual-energy X-ray absorptiometry and preperitoneal fat by ultrasound at 6 years.
RESULTS:
A higher fetal U/C ratio was associated with increased risks of preterm birth and small size for gestational age at birth [odds ratios, 1.41 (95% confidence interval, 1.08-1.85) and 1.63 (95% confidence interval, 1.21-2.19), respectively, per SDS increase in U/C ratio]. Longitudinal growth analyses showed that a higher fetal U/C ratio was associated with persistently lower head circumference, length and weight from third trimester fetal life until childhood (all P < 0.05). The fetal U/C ratio was not associated with total body and abdominal fat measures at 6 years.
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| Keyword(s): | premature labour, prematurity, small for dates, small for gestational age |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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