Primal Health Databank: Study
| Entry No: | 0999 |
| Title: | Breast milk fatty acid composition has a long-term effect on the risk of asthma, eczema, and sensitization. |
| Author(s): | van Elten TM, van Rossem L, et al |
| Reference: | Allergy. 2015 Nov;70(11):1468-76. doi: 10.1111/all.12703. Epub 2015 Aug 26. |
| Place of Study: | The Netherlands |
| Abstract: | The study was nested in the ongoing PIAMA birth cohort. At the child's age of 3 months, 276 mothers provided a breast milk sample. Asthma (N total = 269) and eczema (N total = 274) were self-reported up to the child's age of 14 years. Specific serum IgE levels were measured at the ages of 4, 8 and 12 years (N total = 216). Generalized estimating equations analyses were used to take account of repeated observations.
Asthma up to the age of 14 years is less prevalent in children of allergic mothers receiving breast milk with higher levels of n-3 long chain polyunsaturated (LCP) fatty acids (OR 0.50; 95% CI 0.31-0.79), and more prevalent in children of nonallergic mothers receiving breast milk with higher levels of n-6 LCP (OR 1.86; 95% CI 1.14-3.03). Weaker associations in similar direction were observed for eczema and sensitization. Direction of associations were consistent and of similar magnitude throughout childhood.
CONCLUSION:
The association between breast milk fatty acid composition and asthma, eczema and sensitization persists up to the age of 14 years in children of both allergic and nonallergic mothers. |
| Keyword(s): | asthma in childhood, atopic diseases, breastmilk, eczema, fatty acids, IgE, polyunsaturated fatty acids |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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