Primal Health Databank: Study
| Entry No: | 0993 |
| Title: | Risk of Asthma from Cesarean Delivery Depends on Membrane Rupture |
| Author(s): | Sevelsted A, Stokholm J, et al |
| Reference: | J Pediatr. 2016 Apr;171:38-42.e1-4. doi: 10.1016/j.jpeds.2015.12.066. Epub 2016 Jan 26. |
| Place of Study: | Denmark |
| Abstract: | The Copenhagen Prospective Studies on Asthma in Childhood 2000 is a high-risk birth cohort of 411 Danish children. Asthma was diagnosed prospectively by physicians at the research site, and associations with cesarean delivery were investigated using Cox proportional hazard models. From the Danish national prospective registry the authors included data from 1997-2010. Childhood asthma was defined from recurrent use of inhaled corticosteroids filled at pharmacies. Cesarean delivery was classified as either before or after rupture of membranes, and the risk of asthma was compared with vaginal delivery. Results were adjusted stepwise for age and calendar year, sex, birth weight, gestational age, multiple births, parity, and maternal factors (age, smoking/antibiotics during pregnancy, employment status, and asthma).
RESULTS:
In the Copenhagen Prospective Studies on Asthma in Childhood2000 cohort, the adjusted hazard ratio for asthma was increased by cesarean delivery relative to vaginal birth 2.18 (1.27-3.73). Registry data replicated these findings. Cesarean delivery performed before rupture of membranes carried significantly higher risk of asthma, (incidence rate ratio to vaginal delivery 1.20 [1.16-1.23]) than cesarean delivery after rupture of membranes (incidence rate ratio to vaginal delivery 1.12 [1.09-1.16]).
CONCLUSIONS:
Cesarean delivery appears as a risk factor for childhood asthma. This effect was more pronounced for cesarean delivery performed before rupture of membranes. |
| Keyword(s): | asthma, asthma in childhood, caesarean, cesarean |
| Discussion: | The authors have classified the cesarean births (with or without intact bag of water) in such a way that in both groups there are pre-labor and in-labor cesarean births. They started from the assumption that vaginal microorganisms are protective regarding asthma. |
| See Also: | No related entries mentioned for this entry |
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