Primal Health Databank: Study
| Entry No: | 0978 |
| Title: | Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. |
| Author(s): | Oberg AS, D'Onofrio BM, et al |
| Reference: | JAMA Pediatr. 2016 Jul 25:e160965. doi: 10.1001/jamapediatrics.2016.0965. |
| Place of Study: | Sweden |
| Abstract: | Follow-up of all live births in Sweden between 1992 and 2005, defined in the Medical Birth Register. The register was linked to population registers of familial relations, inpatient and outpatient visits, and education records. Diagnoses of ASD were from 2001 through 2013, and data were analyzed in the 2015-2016 year.
Autism spectrum disorders identified by diagnoses from inpatient and outpatient records between 2001 and 2013. Hazard ratios (HRs) quantified the association between labor induction and offspring ASD. In addition to considering a wide range of measured confounders, comparison of exposure-discordant births to the same woman allowed additional control for all unmeasured factors shared by siblings.
The full cohort included 1 362 950 births, of which 22 077 offspring (1.6%) were diagnosed with ASD by ages 8 years through 21 years. In conventional models of the full cohort, associations between labor induction and offspring ASD were attenuated but remained statistically significant after adjustment for measured potential confounders (HR, 1.19; 95% CI, 1.13-1.24). When comparison was made within siblings whose births were discordant with respect to induction, thus accounting for all environmental and genetic factors shared by siblings, labor induction was no longer associated with offspring ASD (HR, 0.99; 95% CI, 0.88-1.10). |
| Keyword(s): | autism, autistic spectrum disorder, labor induction, labour induction |
| Discussion: | An Australian study, included in this database, had also compared cases and siblings and had reached different conclusions:
Entry No: 0467
Title: Perinatal factors and the development of autism: a population study
Author(s): Glasson EJ, Bower C, Petterson B, de Klerk N, Chaney G, Hallmayer JF, Dean JC
Reference: Arch Gen Psychiatry. 2004 Jun;61(6):618-27
Place of Study: Australia
Abstract: Subjects born in Western Australia between 1980 and 1995 and diagnosed with an autism spectrum disorder by 1999 were included as cases (n = 465). Siblings of the cases (n = 481) and a random population-based control group (n = 1313) were compared with the cases on obstetric information contained in the Maternal and Child Health Research Database of Western Australia. Many negative findings are noticeable. No difference in gestational age at birth (including the proportion of premature infants), weight for gestational age, head circumference, or length were observed between cases and control subjects. Pre-eclampsia did not appear as a risk factor. These negative findings tend to give more importance to perinatal factors. Compared with their siblings, cases were more likely to have been induced (OR, 1.40; 95% CI, 1.03-1.90), experienced fetal distress (OR 1.64), had an Apgar score at 1 minute of 6 or less, and needed longer than 1 minute to breathe spontaneously. Compared with control subjects, cases were more likely to be born after induction (OR 1.43; 95% CI 1.12-1.83), to be born by elective c-section(OR 2.05. P<.001), or to be born by emergency c-section (p .01) |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search