Primal Health Databank: Study
| Entry No: | 0966 |
| Title: | Maternal weight gain in excess of pregnancy guidelines is related to daughters being overweight 40 years later |
| Author(s): | Houghton LC, et al |
| Reference: | Am J Obstet Gynecol. 2016 Feb 18. pii: S0002-9378(16)00334-3. doi: 10.1016/j.ajog.2016.02.034. [Epub ahead of print] |
| Place of Study: | USA |
| Abstract: | This cohort study is based on adult offspring in The Child Health and Development Studies and the Collaborative Perinatal Population pregnancy cohorts originally enrolled in the 1960s. In 2005-2008, 1,108 daughters in their 40s were recruited to the Early Determinants of Mammographic Density study. The authors classified maternal pregnancy weight gain as greater than vs. less than or equal to the 2009 clinical guidelines. They used logistic regression to compare the relative risk of daughters being overweight/obese (body mass index ≥25) at a mean age of 44 between mothers who did not gain or gained more than pregnancy weight gain guidelines , accounting for maternal pre-pregnant body mass index, and daughter's body size at birth and childhood. They also examined potential family related confounding through a comparison of daughter siblings using generalized estimating equations, clustered on sibling units and adjusted for maternal age and race.
Mothers who exceeded guidelines for weight gain in pregnancy were more likely to have daughters who were overweight in their forties [OR=3.4; 95%CI (2.0-5.7)]. The association was of the same magnitude when examining only the siblings whose mother exceeded guidelines in one pregnancy and did not exceed the guidelines in the other pregnancy (OR=3.5; 95%CI=1.2- 10.0).The association was stronger with increasing mothers pre-pregnancy body mass index (p-trend<0.001). The odds ratios for being overweight as a daughter were 2.1(1.0-4.6), 5.6 (2.4-12.7) and 6.9 (2.0-23.8) respectively if mothers pre-pregnancy body mass index was <25, overweight (body mass index 25-<30) or obese (body mass index>30).This pattern holds irrespective of daughters' weight status at birth, at age 4, or at age 20.
CONCLUSION:
These findings support that obesity prevention before pregnancy and strategies to maintain weight gain during pregnancy within the Institute of Medicine guidelines might reduce the risk of being overweight in midlife for the offspring. |
| Keyword(s): | obesity, Overweight |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search