Primal Health Databank: Study
| Entry No: | 0958 |
| Title: | Neonatal respiratory morbidity at term and the risk of childhood asthma. |
| Author(s): | Wood AM, et al |
| Reference: | Arch Dis Child. 2004 Oct;89(10):956-60. |
| Place of Study: | UK |
| Abstract: | This is a retrospective cohort study using Scottish Morbidity Record (SMR) data of maternity (SMR02), neonatal (SMR11), and acute hospital (SMR01) discharges.
SETTING:
Scotland.
PARTICIPANTS:
All singleton births at term between 1992-1995 in 23 Scottish maternity hospitals.
MAIN OUTCOME MEASURES:
Hospital admission with a diagnosis of asthma in the principal position between 1992 and 2000.
RESULTS:
Children who had a diagnosis of transient tachypnoea of the newborn or respiratory distress syndrome were at increased risk of being admitted to hospital with a diagnosis of asthma (hazard ratio (HR) 1.7, 95% confidence interval (95% CI) 1.4 to 2.2, p<0.001). This association was observed both among children delivered vaginally (HR 1.5, 95% CI 1.1 to 2.0, p = 0.007) and among those delivered by caesarean section (HR 2.2, 95% CI 1.6 to 3.0, p<0.001). In the absence of neonatal respiratory morbidity, delivery by caesarean section was weakly associated with the risk of asthma in childhood (HR 1.1, 95% CI 1.0 to 1.2, p = 0.004). The strengths of the associations were similar whether the caesarean delivery was planned or emergency and were not significantly altered by adjustment for maternal, obstetric, and other neonatal characteristics.
CONCLUSIONS:
Neonatal respiratory morbidity at term is associated with an increased risk of asthma in childhood which may explain previously described associations between caesarean delivery and later asthma |
| Keyword(s): | asthma in childhood, neo-natal respiratory problems |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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