Primal Health Databank: Study
| Entry No: | 0956 |
| Title: | Prenatal exposure to maternal stress following bereavement and cardiovascular disease: A nationwide population-based and sibling-matched cohort study. |
| Author(s): | Plana-Ripoll O, Liu X, et al |
| Reference: | Eur J Prev Cardiol. 2015 May 7. pii: 2047487315585294. [Epub ahead of print] |
| Place of Study: | Denmark |
| Abstract: | This population-based study included 2,607,851 children born in Denmark (1970-2008). Of these participants, 73,708 (2.8%) had a CVD (cardiovascular disease) during follow-up (up to 40 years). A total of 50,940 (2.0%) subjects born to mothers who lost a relative during pregnancy or the year before were categorized as exposed. Cox Proportional Hazards models were used to analyse the data. The overall hazard ratio (HR) (95% confidence interval) of having a CVD was 1.13 (1.06-1.20); the estimate was 1.24 (1.11-1.38) for heart disease and 1.27 (1.01-1.60) for hypertension. Additional sibling-matched analyses showed an overall attenuated association (1.08 (0.94-1.24)).
CONCLUSION:
Our results suggested a modest association between prenatal stress and CVD, both in childhood and early adulthood, which could be of importance, especially at an older age when the individuals are followed over a long period. |
| Keyword(s): | bereavement, Cardiovascular disease, cardiovascular diseases, prenatal stress |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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