Primal Health Databank: Study
| Entry No: | 0953 |
| Title: | Mode of delivery and risk of inflammatory bowel disease in the offspring: systematic review and meta-analysis of observational studies. |
| Author(s): | Bruce A, Black M, et al |
| Reference: | Inflamm Bowel Dis. 2014 Jul;20(7):1217-26. doi: 10.1097/MIB.0000000000000075. |
| Place of Study: | UK |
| Abstract: | :The incidence of inflammatory bowel disease (IBD) is increasing worldwide;This study aimed to investigate the relationship between mode of delivery and risk of IBD.
The electronic databases, Embase, CINAHL, and Medline (1948 to present) were searched, reference lists were checked, and no restrictions were assigned. Full texts of potentially relevant articles were evaluated, and included articles were assessed for quality. Raw data were used to calculate unadjusted odds ratios reflecting the risk of developing IBD in those delivered by cesarean. A meta-analysis was performed using RevMan 5 software to obtain a pooled measure of effect. Sensitivity analyses were performed to identify results according to specific study designs.
Seven eligible studies were included; 4 were retrospective cohort design and 3 were case-control studies. The total number of children born by CS in the meta-analysis was 1354, and 11,355 were delivered vaginally. The proportion of IBD in the CS group was 0.249% compared with 0.322% in the vaginal delivery group. The pooled odds ratio of developing IBD when delivered by CS was 1.00 (95% confidence interval, 0.75-1.33).
CONCLUSIONS:
This analysis observed no significant difference in risk of IBD in offspring delivered by CS compared with those born vaginally. |
| Keyword(s): | caesarean, cesarean, inflammatory bowel disease |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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