Primal Health Databank: Study
| Entry No: | 0949 |
| Title: | Gluten consumption during late pregnancy and risk of celiac disease in the offspring: the TEDDY birth cohort. |
| Author(s): | Uusitalo U, Lee HS, et al. |
| Reference: | Am J Clin Nutr. 2015 Nov;102(5):1216-21. doi: 10.3945/ajcn.115.119370. Epub 2015 Oct 7. |
| Place of Study: | international |
| Abstract: | Genetically susceptible children prospectively followed from birth were screened annually for tissue transglutaminase autoantibodies (tTGAs). Children testing persistently positive for tTGAs were further evaluated for celiac disease. Diagnosis of celiac disease was confirmed by intestinal biopsy or was considered likely if the mean tTGA concentration was >100 units in 2 consecutive samples. A questionnaire on the mother's diet in late pregnancy was completed by 3-4.5 mo postpartum. Mothers were divided into 3 groups based on the tertiles of their consumption of gluten-containing foods (servings/d). The association between maternal gluten-containing food consumption and the risk of celiac disease was studied by using a time-to-event analysis.
At the time of analysis, 359 (5%) of the 6546 children developed celiac disease. Compared with the middle category of maternal gluten-containing food consumption (servings/d), low (HR: 0.87; 95% CI: 0.67, 1.13; P = 0.296) and high (HR: 0.84; 95% CI: 0.65, 1.09; P = 0.202) consumption was not associated with risk of celiac disease in the child after adjustment for country, human leukocyte antigen genotype, family history of celiac disease, maternal education, and sex of the child. Median maternal daily consumption frequency of gluten-containing foods was higher (P < 0.0001) in Finland (5.3; IQR: 3.9-6.9), Germany (4.3; IQR: 3.1-5.5), and Sweden (3.7; IQR: 2.8-4.9) than in the United States (3.4; IQR: 2.3-4.9). No significant interaction was found between country of residence and the mothers' consumption of gluten-containing foods in relation to risk of celiac disease.
CONCLUSION:
The frequency of gluten-containing food consumption during late pregnancy is not associated with risk of celiac disease in the offspring. |
| Keyword(s): | coeliac disease, gluten consumption |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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