Primal Health Databank: Study
| Entry No: | 0946 |
| Title: | Early infancy microbial and metabolic alterations affect risk of childhood asthma. |
| Author(s): | Arrieta MC, Stiemsma LT, et al. |
| Reference: | Sci Transl Med. 2015 Sep 30;7(307):307ra152. doi: 10.1126/scitranslmed.aab2271. |
| Place of Study: | Canada |
| Abstract: | The authors compared the gut microbiota of 319 subjects enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) Study, and show that infants at risk of asthma exhibited transient gut microbial dysbiosis during the first 100 days of life. The relative abundance of the bacterial genera Lachnospira, Veillonella, Faecalibacterium, and Rothia was significantly decreased in children at risk of asthma. This reduction in bacterial taxa was accompanied by reduced levels of fecal acetate and dysregulation of enterohepatic metabolites. Inoculation of germ-free mice with these four bacterial taxa ameliorated airway inflammation in their adult progeny, demonstrating a causal role of these bacterial taxa in averting asthma development. These results enhance the potential for future microbe-based diagnostics and therapies, potentially in the form of probiotics, to prevent the development of asthma and other related allergic diseases in children. |
| Keyword(s): | asthma, asthma in childhood, gut flora |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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