Primal Health Databank: Study
| Entry No: | 0931 |
| Title: | Confounding with familial determinants affects the association between mode of delivery and childhood asthma medication - a national cohort study. |
| Author(s): | Braback L , Ekeus C, et al. |
| Reference: | Allergy Asthma Clin Immunol. 2013 Apr 16;9(1):14. doi: 10.1186/1710-1492-9-14. eCollection 2013 |
| Place of Study: | Sweden |
| Abstract: | The association between mode of delivery and dispensed inhaled corticosteroid (ICS) (a marker of asthma) was examined in a register based national cohort (n=199 837). A cohort analysis of all first born children aged 2-5 and 6-9 years was performed. An age-matched sibling-pair analysis was also performed to account for shared genetic and environmental risk factors.
Analyses of first-borns demonstrated that elective caesarean section was associated with an increased risk of dispensed ICS in both 2-5 (adjusted odds ratio (aOR)=1.19, 95% confidence interval (CI) 1.09-1.29) and 6-9 (aOR=1.21, 1.09-1.34) age groups. In the sibling-pair analysis, the increased risk associated with elective caesarean section was confirmed in 2-5 year olds (aOR=1.22, 1.05-1.43) but not in 6-9 year olds (aOR=1.06, 0.78-1.44). Emergency caesarean section and vacuum extraction had some association with dispensed ICS in the analyses of first-borns but these associations were not confirmed in the sibling-pair analyses.
CONCLUSIONS:
Confounding by familial factors affects the association between mode of delivery and dispensed ICS. Despite this confounding, there was some evidence that elective caesarean section contributed to a modestly increased risk of dispensed ICS but only up to five years of age. |
| Keyword(s): | asthma in childhood, caesarean, cesarean |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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