Primal Health Databank: Study
| Entry No: | 0930 |
| Title: | The impact of birth mode of delivery on childhood asthma and allergic diseases--a sibling study. |
| Author(s): | Almqvist C, Cnattingius S, et al. |
| Reference: | Clin Exp Allergy. 2012 Sep;42(9):1369-76. doi: 10.1111/j.1365-2222.2012.04021.x. |
| Place of Study: | Sweden |
| Abstract: | A register-based cohort study with 87 500 Swedish sibling pairs was undertaken. Asthma outcome variables were collected from national health registers as diagnosis or asthma medication (ICD-10 J45-J46; ATC code R03) during the 10th or 13th year of life (year of follow-up). Mode of delivery and confounders were retrieved from the Medical Birth Register. The data were analysed both as a cohort and with sibling control analysis which adjusts for unmeasured familial confounding.
In the cohort analyses, there was an increased risk of asthma medication and asthma diagnosis during year of follow-up in children born with CS (adjusted ORs, 95% CI 1.13, 1.04-1.24 and 1.10, 1.03-1.18 respectively). When separating between emergency and elective CS the effect on asthma medication remained for emergency CS, but not for elective CS, while both groups had significant effects on asthma diagnosis compared with vaginal delivery. In sibling control analyses, the effect of elective CS on asthma disappeared, while similar but non-significant ORs of medication were obtained for emergency CS.
CONCLUSIONS AND CLINICAL RELEVANCE:
An increased risk of asthma medication in the group born by emergency CS, but not elective, suggests that there is no causal effect due to vaginal microflora. A more probable explanation should be sought in the indications for emergency CS |
| Keyword(s): | asthma in childhood, caesarean, cesarean |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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