Primal Health Databank: Study
| Entry No: | 0918 |
| Title: | The Effect of Early Life Antibiotic Exposures on Diarrheal Rates Among Young Children in Vellore, India. |
| Author(s): | Rogawski ET, Westreich D, et al. |
| Reference: | Pediatr Infect Dis J. 2015 Mar 3. [Epub ahead of print] |
| Place of Study: | India |
| Abstract: | In a prospective observational cohort study, the authors assessed whether antibiotic exposures from 0-5 months affected rates of diarrhea up to age 3 years among 465 children from Vellore, India. Adjusting for treatment indicators, they modeled diarrheal rates among children exposed and unexposed to antibiotics using negative binomial regression. They further assessed whether the effect of antibiotics on diarrheal rates was modified by exclusive breastfeeding at 6 months.
More than half of children (n=267, 57.4%) were given at least one course of antibiotics in the first 6 months of life. The adjusted relative incidence rate of diarrhea was 33% higher among children who received antibiotics under 6 months of age compared to those who did not (incidence rate ratio: 1.33, 95% confidence interval: 1.12, 1.57). Children who were exclusively breastfed until 6 months of age did not have increased diarrheal rates following antibiotic use.
CONCLUSIONS::
Antibiotic exposures early in life were associated with increased rates of diarrhea in early childhood. Exclusive breastfeeding might protect against this negative impact. |
| Keyword(s): | antibiotics, diarrhea |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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