Primal Health Databank: Study
| Entry No: | 0913 |
| Title: | Increased food diversity in the first year of life is inversely associated with allergic diseases. |
| Author(s): | Roduit C, Depner M, et al. |
| Reference: | J Allergy Clin Immunol. 2014 Apr;133(4):1056-64. doi: 10.1016/j.jaci.2013.12.1044. Epub 2014 Feb 6. |
| Place of Study: | Switzerland |
| Abstract: | Eight hundred fifty-six children who participated in a birth cohort study, Protection Against Allergy Study in Rural Environments/EFRAIM, were included. Feeding practices were reported by parents in monthly diaries during the first year of life. Data on environmental factors and allergic diseases were collected from questionnaires administered from birth up to 6 years of age.
An increased diversity of complementary food introduced in the first year of life was inversely associated with asthma with a dose-response effect (adjusted odds ratio with each additional food item introduced, 0.74 [95% CI, 0.61-0.89]). A similar effect was observed for food allergy and food sensitization. Furthermore, increased food diversity was significantly associated with an increased expression of forkhead box protein 3 and a decreased expression of Cε germline transcript.
CONCLUSION:
An increased diversity of food within the first year of life might have a protective effect on asthma, food allergy, and food sensitization and is associated with increased expression of a marker for regulatory T cells. |
| Keyword(s): | asthma, asthma in childhood, breastfeeding, food allergy, infant feeding |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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