Primal Health Databank: Study
| Entry No: | 0911 |
| Title: | Prenatal and early life factors and risk of Parkinson's disease. |
| Author(s): | Gardener H, Gao X, et al. |
| Reference: | Mov Disord. 2010 Aug 15;25(11):1560-7. doi: 10.1002/mds.23339. |
| Place of Study: | USA |
| Abstract: | The study population comprised participants in two prospective cohorts: the Nurses' Health Study (121,701 female nurses followed up from 1976-2002) and the Health Professionals Follow-up Study (51,529 male health professionals followed up from 1986-2002). PD risk was examined in relation to season of birth, birthweight, parental age at birth, preterm birth, multiple birth, ever having been breast-fed, and handedness. The authors identified 659 incident PD cases. No significant relation with PD was observed for birthweight, paternal age, preterm birth, multiple birth, and having been breast-fed. A modest nonsignificant association was suggested for season of birth (30% higher risk of PD associated with spring versus winter birth) and for older maternal age at birth (75% increased risk among those with mothers aged 30 years and older versus younger than 20 years). Left-handedness was associated with a 62% increased risk of PD in women but not in men. Further investigation of the relation between prenatal, perinatal, or neonatal factors and PD in other study populations is suggested. |
| Keyword(s): | gender, handedness, Parkinson's disease |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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