Primal Health Databank: Study
| Entry No: | 0910 |
| Title: | Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study. |
| Author(s): | Sun W, Svendsen ER, et al. |
| Reference: | J Asthma. 2014 Dec 24:1-21. [Epub ahead of print] |
| Place of Study: | Sweden |
| Abstract: | A multi-center prospective cohort study was conducted among children at high risk for allergic sensitization. A validated questionnaire was used to prospectively collect information on antibiotic use and potential risk factors for wheezing from parents or guardians of 606 children from 3 European countries at 6, 12, 24, and 36 months of age. Multivariate linear and logistic regression models were used to adjust for potential confounders and effect modifiers and to estimate the association of antibiotic use with the development of early childhood wheezing. Results: Of the antibiotics assessed, only macrolides use in the first year of life was associated with increasing risk for wheezing by 36 months, after adjusting for gender, socioeconomic status, breast feeding > 6 months, tobacco smoke exposure, family history of asthma, and respiratory infection (RR = 1.09; 95% CI 1.05 - 1.13). To avoid a bias by indication, the authors analyzed children with and without respiratory infection separately. Similar associations were observed for macrolides use in children who had no respiratory infection. Conclusions: A positive association between macrolides use in the first year of life and wheezing until 36 months old which was independent of the effect of respiratory infection. |
| Keyword(s): | antibiotics, wheeze, wheezing |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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