Primal Health Databank: Study
| Entry No: | 0907 |
| Title: | Preeclampsia, Placental Insufficiency, and Autism Spectrum Disorder or Developmental Delay. |
| Author(s): | Walker CK, Krakowiak P, et al. |
| Reference: | JAMA Pediatr. 2014 Dec 8. doi: 10.1001/jamapediatrics.2014.2645. [Epub ahead of print] |
| Place of Study: | USA |
| Abstract: | The Childhood Autism Risks from Genetics and the Environment (CHARGE) study is a population-based, case-control investigation of ASD (autistic spectrum disorder) and/or DD (developmental delay) origins. Children from 20 California counties aged 24 to 60 months at the time of recruitment and living in catchment areas with a biological parent fluent in English or Spanish were enrolled from January 29, 2003, through April 7, 2011. Children with ASD (n = 517) and DD (n = 194) were recruited through the California Department of Developmental Services, the Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, and referrals. Controls with typical development (TD) (n = 350) were randomly selected from birth records and frequency matched on age, sex, and broad geographic region. Physicians diagnosing preeclampsia were masked to neurodevelopmental outcome, and those assessing neurodevelopmental function were masked to preeclampsia status.
Preeclampsia and placental insufficiency were self-reported and abstracted from medical records.
The Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised were used to confirm ASD, whereas children with DD and TD were confirmed by Mullen Scales of Early Learning and Vineland Adaptive Behavior Scales and were free of autistic symptoms. Hypotheses were formulated before data collection.
Children with ASD were twice as likely to have been exposed in utero to preeclampsia as controls with TD after adjustment for maternal educational level, parity, and prepregnancy obesity (adjusted odds ratio, 2.36; 95% CI, 1.18-4.68); risk increased with greater preeclampsia severity (test for trend, P = .02). Placental insufficiency appeared responsible for the increase in DD risk associated with severe preeclampsia (adjusted odds ratio, 5.49; 95% CI, 2.06-14.64). |
| Keyword(s): | Asperger's syndrome, autism, autistic spectrum disorder, pre-eclampsia, preeclampsia |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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