Primal Health Databank: Study
| Entry No: | 0906 |
| Title: | Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity |
| Author(s): | Mueller NT, Whyatt R, et al |
| Reference: | Int J Obes (Lond). 2014 Nov 11. doi: 10.1038/ijo.2014.180. [Epub ahead of print] |
| Place of Study: | USA |
| Abstract: | Of the 727 mothers enrolled in the Northern Manhattan Mothers and Children Study, the authors analyzed the 436 mother-child dyads followed until 7 years of age with complete data. They ascertained prenatal antibiotic use by a questionnaire administered late in the third trimester, and delivery mode by medical record. They derived age- and sex-specific body mass index (BMI) z-scores using the CDC SAS Macro, and defined obesity as BMI z⩾95th percentile. They used binary regression with robust variance and linear regression models adjusted for maternal age, ethnicity, pre-gravid BMI, maternal receipt of public assistance, birth weight, sex, breastfeeding in the first year and gestational antibiotics or delivery mode.Results:Compared with children not exposed to antibiotics during the second or third trimester, those exposed had 84% (33-154%) higher risk of obesity, after multivariable adjustment. Second or third trimester antibiotic exposure was also positively associated with BMI z-scores, waist circumference and % body fat (all P<0.05). Independent of prenatal antibiotic usage, CS was associated with 46% (8-98%) higher offspring risk of childhood obesity. Associations were similar for elective and non-elective CS.Conclusions:In this cohort, CS and exposure to antibiotics in the second or third trimester were associated with higher offspring risk of childhood obesity. |
| Keyword(s): | antibiotics, obesity, obesity in chilhood |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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