Primal Health Databank: Study
| Entry No: | 0901 |
| Title: | Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder. |
| Author(s): | Schmidt RJ,, Tancredi DJ, et al. |
| Reference: | Am J Epidemiol. 2014 Sep 22. pii: kwu208. [Epub ahead of print] |
| Place of Study: | USA |
| Abstract: | The authors examined maternal iron intake in relation to ASD risk in California-born children enrolled in a population-based case-control study (the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study) from 2003 to 2009 with a diagnosis of ASD (n = 520) or typical development (n = 346) that was clinically confirmed using standardized assessments. Mean maternal daily iron intake was quantified on the basis of frequency, dose, and brands of supplements and cereals consumed each month from 3 months before pregnancy through the end of pregnancy and during breastfeeding (the index period), as reported in parental interviews. Mothers of cases were less likely to report taking iron-specific supplements during the index period (adjusted odds ratio = 0.63, 95% confidence interval: 0.44, 0.91), and they had a lower mean daily iron intake (51.7 (standard deviation, 34.0) mg/day) than mothers of controls (57.1 (standard deviation, 36.6) mg/day; P = 0.03). The highest quintile of iron intake during the index period was associated with reduced ASD risk compared with the lowest (adjusted odds ratio = 0.49, 95% confidence interval: 0.29, 0.82), especially during breastfeeding. Low iron intake significantly interacted with advanced maternal age and metabolic conditions; combined exposures were associated with a 5-fold increased ASD risk. Further studies of this link between maternal supplemental iron and ASD are needed to inform ASD prevention strategies. |
| Keyword(s): | autism, autistic spectrum disorder, iron, pre-eclampsia, preeclampsia |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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