Primal Health Databank: Study
| Entry No: | 0887 |
| Title: | Antibiotic use in the first year of life and asthma in early childhood. |
| Author(s): | Celedon JC, Fuhlbrigge A, et al. |
| Reference: | Clin Exp Allergy. 2004 Jul;34(7):1011-6. |
| Place of Study: | USA |
| Abstract: | Longitudinal follow-up of 4408 children enrolled in a health maintenance organization (HMO) from birth to the age of 5 years.
After adjusting for sex and illnesses of the lower respiratory tract (LRIs), the authors found a significant association between antibiotic use in the first year of life and asthma between the ages of 1 and 2 years (odds ratio (OR) for 1-2 vs. no courses of antibiotics=1.9, 95% confidence interval (CI)=1.3-2.7; OR for 3-4 vs. no courses of antibiotics=1.6, 95% CI=1.1-2.4; OR for at least 5 vs. no courses of antibiotics=2.1, 95% CI=1.5-3.2). After adjustment for sex and LRIs in the first year of life, there was no significant association between antibiotic use in the first year of life and asthma that was initially diagnosed between the ages of 2 and 5 years and that persisted up to the age of 5 years (OR for 1-2 vs. no courses of antibiotics=1.1, 95% CI=0.8-1.4; OR for 3-4 vs. no courses of antibiotics=1.3, 95% CI=0.9-1.8; OR for at least 5 vs. no courses of antibiotics=1.0, 95% CI=0.7-1.4). |
| Keyword(s): | antibiotics, asthma, asthma in childhood |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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