Primal Health Databank: Study

Entry No:0874
Title:Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort.
Author(s):Mathews CA, Scharf JM, et al.
Reference:Br J Psychiatry. 2014 Jan;204:40-5. doi: 10.1192/bjp.bp.112.125468. Epub 2013 Nov 21.
Place of Study:UK
Abstract: Prospective longitudinal pre-birth cohort in order to examine the association between pre- and perinatal exposures and Tourette syndrome/chronic tic disorder in the Avon Longitudinal Study of Parents and Children (ALSPAC) Relationships between exposures and Tourette syndrome/chronic tic disorder were examined in 6090 children using logistic regression. Maternal alcohol and cannabis use, inadequate maternal weight gain and parity were associated with Tourette syndrome or Tourette syndrome/chronic tic disorder. Other previously reported exposures, including birth weight and prenatal maternal smoking, were not associated with Tourette syndrome/chronic tic disorder. CONCLUSIONS: This study supports previously reported relationships between Tourette syndrome/chronic tic disorder and prenatal alcohol exposure, and identifies additional previously unexplored potential prenatal risk factors.
Keyword(s):alcohol in pregnancy, cannabis, Tourette syndrome
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