Primal Health Databank: Study
| Entry No: | 0866 |
| Title: | Association of gestational maternal hypothyroxinemia and increased autism risk. |
| Author(s): | Roman GC, Ghassabian A, etc.. |
| Reference: | Ann Neurol. 2013 Aug 13. doi: 10.1002/ana.23976. [Epub ahead of print] |
| Place of Study: | Netherlands |
| Abstract: | The mother-and-child cohort of the Generation R Study (Rotterdam, the Netherlands) began prenatal enrollment between 2002 and 2006. At a mean gestational age of 13.4 weeks (standard deviation = 1.9, range = 5.9-17.9), maternal thyroid function tests (serum thyrotropin [TSH], free thyroxine [fT4 ], and thyroid peroxidase [TPO] antibodies) were assessed in 5,100 women. The authors defined severe maternal hypothyroxinemia as fT4 < 5th percentile with normal TSH. Six years later, parents reported behavioral and emotional symptoms in 4,039 children (79%) using the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist and/or the Social Responsiveness Scale (SRS). We defined a probable autistic child by a PDP score > 98th percentile and SRS score in the top 5% of the sample (n = 81, 2.0%).
Severe maternal hypothyroxinemia (n = 136) was associated with an almost 4-fold increase in the odds of having a probable autistic child (adjusted odds ratio = 3.89, 95% confidence interval [CI] = 1.83-8.20, p < 0.001). Using PDP scores, children of mothers with severe hypothyroxinemia had higher scores of autistic symptoms by age 6 years (adjusted B = 0.23, 95% CI = 0.03-0.37); SRS results were similar. No risk was found for children of TPO-antibody-positive mothers (n = 308). |
| Keyword(s): | autism, autism, autistic spectrum disorder, drugs in pregnancy, hypothyroidism |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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