Primal Health Databank: Study
| Entry No: | 0864 |
| Title: | Asthma During Pregnancy and Clinical Outcomes in Offspring: A National Cohort Study. |
| Author(s): | Tegethoff M, Olsen J, et al. |
| Reference: | Pediatrics. 2013 Aug 5. [Epub ahead of print] |
| Place of Study: | Denmark |
| Abstract: | The authors studied pregnant women from the Danish National Birth Cohort (births: 1996-2002; prospective data) giving birth to live singletons (n = 66 712 mother-child pairs), with 4145 (6.2%) women suffering from asthma during pregnancy. They estimated the associations between asthma during pregnancy and offspring diseases (International Classification of Diseases, 10th Revision diagnoses from national registries), controlling for potential confounders and validating findings by secondary analyses.RESULTS:Offspring median age at end of follow-up was 6.2 (3.6-8.9) years. Asthma was associated with an increased offspring risk of infectious and parasitic diseases (hazard ratio [HR] 1.34; 95% confidence interval [CI] 1.23-1.46), diseases of the nervous system (HR 1.43; CI 1.18-1.73), ear (HR 1.33; CI 1.19-1.48), respiratory system (HR 1.43; CI 1.34-1.52), and skin (HR 1.39; CI 1.20-1.60), and potentially (not confirmed in secondary analyses) of endocrine and metabolic disorders (HR 1.26; CI 1.02-1.55), diseases of the digestive system (HR 1.17; CI 1.04-1.32), and malformations (odds ratio 1.13; CI 1.01-1.26), but not of neoplasms, mental disorders, or diseases of the blood and immune system, circulatory system, musculoskeletal system, and genitourinary system.CONCLUSIONS: In line with previous data on selected outcomes, asthma during pregnancy may be a risk factor for numerous offspring diseases. |
| Keyword(s): | asthma in pregnancy |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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