Primal Health Databank: Study
| Entry No: | 0857 |
| Title: | Maternal Preeclampsia and Bone Mineral Density of the Adult Offspring. |
| Author(s): | Miettola S, Hovi P, et al. |
| Reference: | Am J Obstet Gynecol. 2013 Jun 19. pii: S0002-9378(13)00644-3. doi: 10.1016/j.ajog.2013.06.028. [Epub ahead of print] |
| Place of Study: | Finland |
| Abstract: |
, Hovi P, Andersson S, Strang-Karlsson S, Pouta A, Laivuori H, Järvenpää AL, Eriksson JG, Mäkitie O, Kajantie E.
Source
National Institute for Health and Welfare, Oulu, Finland; Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
Abstract
OBJECTIVE:
Preterm birth at very low birth weight (VLBW; <1500 g) is associated with cardiometabolic risk factors and reduced bone mineral density (BMD) in the adult offspring. Preeclampsia is a frequent cause of preterm birth and is also associated with cardiometabolic risk factors in the offspring. Whether it is associated with BMD is not known.
The authors evaluated skeletal health in participants of the Helsinki Study of Very Low Birth Weight Adults: 144 born at VLBW and 139 born at term. From the VLBW and term offspring a respective 32 and 11 were born from pregnancy complicated by preeclampsia. They measured BMD at age 18.5 to 27.1 years by dual X-ray absorptiometry.
VLBW adults exposed to maternal preeclampsia had higher lumbar spine Z score (mean -0.44, compared to -1.07 in VLBW unexposed adults, p=0.002), femoral neck Z score (-0.05 vs. -0.53, p=0.003) and whole body BMD Z score (-0.14 vs. 0.72, p=0.001). Corresponding Z scores for those born at term were -0.02 (preeclampsia) and -0.45 (no preeclampsia) for lumbar spine (p=0.2), 0.78 and 0.08 for femoral neck (p=0.02) and 0.02 and -0.31 for whole body BMD Z score (p=0.08). The results survived adjustment for offspring current height, BMI, leisure time physical activity, socio-economic position, smoking, and maternal smoking during pregnancy, and maternal prepregnancy BMI.
CONCLUSIONS:
Young adults exposed to maternal preeclampsia have higher BMD than those not exposed. This difference is seen among those born at VLBW and seems also to be present among those born at term.
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| Keyword(s): | birth weight, bone density, low birthweight, preeclampsia |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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