Primal Health Databank: Study
| Entry No: | 0855 |
| Title: | Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood. |
| Author(s): | Havstad S, Wegienka G, et al. |
| Reference: | J Allergy Clin Immunol. 2011 Oct;128(4):880-885.e4. doi: 10.1016/j.jaci.2011.06.039. Epub 2011 Aug 5. |
| Place of Study: | USA |
| Abstract: | The authors sought to examine within-individual longitudinal trends in total IgE levels during early childhood and assess the effect of indoor prenatal pet exposure on those trends. Also, we sought to use a statistical method that was flexible enough to allow and account for unequally spaced study contacts and missing data.
Using the population-based Wayne County Health, Environment, Allergy and Asthma Longitudinal Study birth cohort (62% African American), the aauthors analyzed 1187 infants with 1 to 4 measurements of total IgE collected from birth to 2 years of age. Effects of pet exposure on the shape and trajectory of IgE levels were assessed by using a multilevel longitudinal model, accommodating repeated measures, missing data, and the precise time points of data collection.
The best-fit shape to the trajectory of IgE levels was nonlinear, with an accelerated increase before 6 months. Total IgE levels were lower across the entire early-life period when there was prenatal indoor pet exposure (P < .001). This effect was statistically significantly stronger in children delivered by means of cesarean section versus those delivered vaginally (P < .001 and P < .06, respectively) and in those born to non-African American (P < .001) versus African American (P < .3) mothers.
CONCLUSION:
Pet exposure and delivery mode might be markers of infant exposure to distinct microbiomes. The effect of exposures might vary by race, suggesting a differential effect by ancestry
|
| Keyword(s): | allergic disease, cats, dogs, IgE |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search