Primal Health Databank: Study
| Entry No: | 0821 |
| Title: | Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study. |
| Author(s): | Penders J, et al., Notenboom ML, Mommers M, et al. |
| Reference: | Clin Exp Allergy. 2011 Mar;41(3):407-16. doi: 10.1111/j.1365-2222.2010.03672.x. Epub 2011 Jan 24 |
| Place of Study: | Netherland |
| Abstract: | In the KOALA Birth Cohort Study, maternal blood samples (n=1275) at 34-36 weeks of pregnancy were assayed for n-6 and n-3 long-chain polyunsaturated fatty acids (LCPs). The full spectrum of offspring atopic manifestations (wheeze, asthma, allergic rhinoconjunctivitis, eczema, atopic dermatitis, allergic sensitization, and high total IgE) until the age of 6-7 years was assessed by repeated parental questionnaires and measurements of total and specific IgE. Associations of maternal fatty acid status with child atopic outcomes were analysed using multivariable logistic regression and generalized estimating equations for repeated measurements.
High ratio of maternal n-6 vs. n-3 LCPs was associated with a lower risk of eczema in the child (P for trend 0.012). More specifically, we found a decreased risk of eczema in the first 7 months of life with increasing arachidonic acid levels (P for trend 0.013). No associations were found between maternal fatty acids and offspring airway-related atopic manifestations, sensitization, or high total IgE.
CONCLUSION AND CLINICAL RELEVANCE:
The development of atopic disorders in early childhood is associated with prenatal exposure to n-6 vs. n-3 fatty acids, but with inconsistencies between different manifestations. Further exploration of associations with maternal diet and genetic variants in genes regulating fatty acid metabolism are required. This study shows that the influence of prenatal exposure to fatty acids on the risk of eczema in the child is limited to the first year of life. |
| Keyword(s): | allergic disease, asthma, asthma in childhood, atopic diseases, Atopic eczema |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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