Primal Health Databank: Study
| Entry No: | 0816 |
| Title: | Preterm birth and risk of medically treated hypothyroidism in young adulthood |
| Author(s): | Crump C, Sundquist K, et al. |
| Reference: | Clin Endocrinol (Oxf). 2011 Aug;75(2):255-60. doi: 10.1111/j.1365-2265.2011.04034.x |
| Place of Study: | Sweden |
| Abstract: | National cohort study of 629,806 individuals born in Sweden from 1973 through 1979, including 27,935 born preterm (<37 weeks).
Preterm birth was associated with increased relative odds of thyroid hormone prescription in young adulthood, after adjusting for foetal growth and other potential confounders. This association appeared stronger among twins than singletons (P = 0·04 for the interaction). Twins had increased relative odds across the full range of preterm gestational ages, whereas singletons had increased relative odds only if born very preterm (23-31 weeks). Among twins and singletons, respectively, adjusted odds ratios for individuals born preterm (<37 weeks) were 1·54 (95% CI, 1·11-2·14) and 1·08 (95% CI, 0·98-1·19), and for individuals born very preterm (23-31 weeks) were 2·62 (95% CI, 1·30-5·27) and 1·59 (95% CI, 1·18-2·14), relative to full-term births.
CONCLUSIONS:
This national cohort study suggests that preterm birth is associated with an increased risk of medically treated hypothyroidism in young adulthood. This association was independent of foetal growth and appeared stronger among twins than singletons. Additional studies are needed to confirm these new findings in other populations and to elucidate the mechanisms |
| Keyword(s): | hypothyroidism, prematurity |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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