Primal Health Databank: Study
| Entry No: | 0813 |
| Title: | Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy |
| Author(s): | Pistiner M, Gold DR, et al. |
| Reference: | J Allergy Clin Immunol. 2008 Aug;122(2):274-9. Epub 2008 Jun 20 |
| Place of Study: | USA |
| Abstract: | The authors examined the relation between mode of delivery and the development of atopy and allergic diseases among 432 children with a parental history of atopy followed from birth to age 9 years. Asthma was defined as physician-diagnosed asthma and wheeze in the previous year, and allergic rhinitis was defined as physician-diagnosed allergic rhinitis and naso-ocular symptoms apart from colds in the previous year. Atopy was considered present at school age if there was 1 or more positive skin test response or specific IgE to common allergens. Stepwise logistic regression was used to study the relation between cesarean delivery and the outcomes of interest.
After adjustment for other covariates, children born by cesarean section had 2-fold higher odds of atopy than those born by vaginal delivery (odds ratio, 2.1; 95% CI, 1.1-3.9). In multivariate analyses birth by cesarean section was significantly associated with increased odds of allergic rhinitis (odds ratio, 1.8; 95% CI, 1.0-3.1) but not with asthma.
CONCLUSIONS: These findings suggest that cesarean delivery is associated with allergic rhinitis and atopy among children with a parental history of asthma or allergies. This could be explained by lack of contact with the maternal vaginal/fecal flora or reduced/absent labor during cesarean delivery.
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| Keyword(s): | allergic disease, allergic rhinitis, asthma, asthma in childhood, caesarean, cesarean, childhood asthma |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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