Primal Health Databank: Study
| Entry No: | 0802 |
| Title: | Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort. |
| Author(s): | Donahue SM, Rifas-Shiman SL, et al. |
| Reference: | Am J Clin Nutr. 2011 Apr;93(4):780-8. Epub 2011 Feb 10. |
| Place of Study: | USA |
| Abstract: | In mother-child pairs in the Project Viva cohort, the authors assessed midpregnancy fatty acid intakes (n = 1120), maternal plasma PUFA concentrations (n = 227), and umbilical cord plasma PUFA concentrations (n = 302). They performed multivariable regression analyses to examine independent associations of n-3 PUFAs, including docosahexaenoic and eicosapentaenoic acids (DHA EPA), n-6 PUFAs, and the ratio of n-6:n-3 PUFAs, with child adiposity at age 3 y measured by the sum of subscapular and triceps skinfold thicknesses (SS TR) and risk of obesity (body mass index ≥95th percentile for age and sex).
Mean (±SD) DHA EPA intake was 0.15 ± 0.14 g DHA EPA/d, maternal plasma concentration was 1.9 ± 0.6%, and umbilical plasma concentration was 4.6 ± 1.2%. In children, SS TR was 16.7 ± 4.3 mm, and 9.4% of children were obese. In the adjusted analysis, there was an association between each SD increase in DHA EPA and lower child SS TR [-0.31 mm (95% CI: -0.58, -0.04 mm) for maternal diet and -0.91 mm (95% CI: -1.63, -0.20 mm) for cord plasma] and lower odds of obesity [odds ratio (95% CI): 0.68 (0.50, 0.92) for maternal diet and 0.09 (0.02, 0.52) for cord plasma]. Maternal plasma DHA EPA concentration was not significantly associated with child adiposity. A higher ratio of cord plasma n-6:n-3 PUFAs was associated with higher SS TR and odds of obesity.
CONCLUSION: An enhanced maternal-fetal n-3 PUFA status was associated with lower childhood adiposity. |
| Keyword(s): | nutrition in pregnancy, obesity, sea fish |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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