Primal Health Databank: Study
| Entry No: | 0798 |
| Title: | Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma |
| Author(s): | Kozyrskyj AL, Mai XM, et al. |
| Reference: | Am J Respir Crit Care Med. 2008 Jan 15;177(2):142-7. Epub 2007 Oct 11 |
| Place of Study: | Canada |
| Abstract: | Using Manitoba, Canada's, health care and prescription databases, this longitudinal study assessed the association between maternal distress during the first year of life and onward, and asthma at age 7 in a 1995 birth cohort of 13,907 children.
Maternal distress was defined on the basis of health care or prescription medication use for depression or anxiety. Asthma status was derived from health care and prescription records for asthma, using a definition validated by comparison to pediatric allergist diagnosis. Multiple logistic regression was used to determine the likelihood of asthma (odds ratio [OR], 95% confidence interval [95% CI]). Independent of well-known asthma risk factors, our population-based study of a non-high-risk cohort demonstrated an increased risk of childhood asthma (OR, 1.25; 95% CI, 1.01-1.55) among children exposed to continued maternal distress from birth until age 7. Exposure to maternal depression and anxiety limited to the first year of life did not have a demonstrable association with subsequent asthma. Of interest, we observed that the risk of asthma associated with continued maternal distress was increased in children living in high- versus low-income households (OR, 1.44; 95% CI, 1.12-1.85).
CONCLUSIONS:
Maternal distress in early life plays a role in the development of childhood asthma, especially if it continues beyond the postpartum period. |
| Keyword(s): | asthma, asthma in childhood, maternal emotional state |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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