Primal Health Databank: Study
| Entry No: | 0797 |
| Title: | Mothers' anxiety during pregnancy is associated with asthma in their children. |
| Author(s): | Cookson H, Granell R, et al. |
| Reference: | J Allergy Clin Immunol. 2009 Apr;123(4):847-53.e11. |
| Place of Study: | Australia |
| Abstract: | The Avon Longitudinal Study of Parents and Children is a population-based birth cohort recruited during pregnancy. Data were available on maternal anxiety scores and asthma at age 7(1/2) years in 5810 children. Anxiety was assessed at 18 and 32 weeks of gestation by using the validated Crown-Crisp Experiential Index. Asthma was defined at age 7(1/2) years as doctor-diagnosed asthma with current symptoms or treatment in the previous 12 months. Multivariable logistic regression was used to determine the association of prenatal anxiety with asthma (odds ratio; 95% CI).
Independent of postnatal anxiety and adjusted for a number of likely confounders, there was a higher likelihood of asthma at age 7(1/2) years (odds ratio, 1.64; 95% CI, 1.25-2.17) in children of mothers in the highest compared with lowest quartile of anxiety scores at 32 weeks of gestation, with evidence for a dose-response (P value for trend <0.001).
CONCLUSIONS:
Maternal anxiety symptoms as an indicator of stress during fetal life may program the development of asthma during childhood. |
| Keyword(s): | asthma, asthma in childhood, stress during pregnancy |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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