Primal Health Databank: Study
| Entry No: | 0771 |
| Title: | Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial |
| Author(s): | Olsen SF, Østerdal ML, Salvig JD, et al. |
| Reference: | Am J Clin Nutr. 2008 Jul;88(1):167-75 |
| Place of Study: | Denmark |
| Abstract: | In 1990, a population-based sample of 533 women with normal pregnancies were randomly assigned 2:1:1 to receive four 1-g gelatin capsules/d with fish oil providing 2.7 g n-3 PUFAs (n = 266); four 1-g, similar-looking capsules/d with olive oil (n = 136); or no oil capsules (n = 131). Women were recruited and randomly assigned around gestation week 30 and asked to take capsules until delivery. Among 531 live-born children, 528 were identified in registries and 523 were still alive by August 2006. Diagnoses from the International Coding of Diseases version 10 were extracted from a mandatory registry that recorded diagnoses reported from hospital contacts.
During the 16 y that passed since childbirth, 19 children from the fish oil and olive oil groups had received an asthma-related diagnosis; 10 had received the diagnosis allergic asthma. The hazard rate of asthma was reduced by 63% (95% CI: 8%, 85%; P = 0.03), whereas the hazard rate of allergic asthma was reduced by 87% (95% CI: 40%, 97%; P = 0.01) in the fish oil compared with the olive oil group.
These results support that increasing n-3 PUFAs in late pregnancy may carry an important prophylactic potential in relation to offspring asthma. |
| Keyword(s): | asthma in childhood, fish oil |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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