Primal Health Databank: Study
| Entry No: | 0769 |
| Title: | Association of Intrauterine and Early-Life Exposures With Age at Menopause in the Sister Study |
| Author(s): | Steiner AZ, D'Aloisio AA, Deroo LA, et al. |
| Reference: | Am J Epidemiol. 2010 Jun 9. [Epub ahead of print] |
| Place of Study: | USA |
| Abstract: | The authors hypothesized that early-life events could affect the number of a woman's oocytes and determine age at menopause. To test their hypothesis, the authors conducted a secondary analysis of baseline data from 22,165 participants in the Sister Study (2003-2007) who were aged 35-59 years at enrollment. To estimate the association between early-life events and age at natural menopause, the authors used Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals, adjusting for current age, race/ethnicity, education, childhood family income, and smoking history. Earlier menopause was associated with in-utero diethylstilbestrol exposure (hazard ratio (HR) = 1.45, 95% confidence interval (CI): 1.27, 1.65). Suggestive associations included maternal prepregnancy diabetes (HR = 1.33, 95% CI: 0.89, 1.98) and low birth weight (HR = 1.09, 95% CI: 0.99, 1.20). Having a mother aged 35 years or older at birth appeared to be associated with a later age at menopause (HR = 0.95, 95% CI: 0.89, 1.01). Birth order, in-utero smoke exposure, and having been breastfed were not related to age at menopause. In-utero and perinatal events may subsequently influence age at menopause. |
| Keyword(s): | DES, menopause, paracetamol |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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