Primal Health Databank: Study
| Entry No: | 0762 |
| Title: | Glucose Intolerance and Cardiometabolic Risk in adolescent exposed to maternal Gestational Diabetes - a 15-year follow-up study |
| Author(s): | Tam WH, Ma RC, Yang X, et al. |
| Reference: | Diabetes Care. 2010 Mar 9. [Epub ahead of print] |
| Place of Study: | Hong Kong |
| Abstract: | Adolescent offspring of women with history of gestational diabetes (GD) was evaluated for their cardiometabolic risks at a mean age of 15 years. Research 129 adolescents who were assessed for their cardiometabolic risks at 8 years of age were reassessed at 15 years of age. Adolescent offspring of mothers with GD had similar blood pressure, plasma lipid profile and rate of abnormal glucose tolerance as controls. In utero hyperinsulinemia was associated with 17-fold increase in metabolic syndrome and 10-fold increase in overweight at adolescence, independent of birth weight, Tanner stage, maternal GD status and mother's BMI. Conclusions: In utero environment of hyperinsulinemia, irrespective of the degree of maternal GD, was associated with increased risk of overweight and metabolic syndrome during early adolescence in the offspring. |
| Keyword(s): | gestational diabetes, glucose tolerance, hyperinsulinemia, metabolic syndrome, Overweight |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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