Primal Health Databank: Study
| Entry No: | 0756 |
| Title: | Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life |
| Author(s): | Painter RC, Osmond C, Gluckman P, et al. |
| Reference: | BJOG. 2008 Sep;115(10):1243-9 |
| Place of Study: | Netherlands |
| Abstract: | DESIGN: Historical cohort study. SETTING: Interview during a clinic or home visit or by telephone. POPULATION: Men and women born in the Wilhelmina Gasthuis in Amsterdam between November 1943 and February 1947. METHODS: interview cohort members (F1) born around the time of the 1944-45 Dutch famine, who were exposed or unexposed to famine in utero, about their offspring (F2). MAIN OUTCOME MEASURES: Birthweight, birth length, ponderal index and health in later life (as reported by F1) of the offspring (F2) of 855 participating cohort members, according to F1 famine exposure in utero. RESULTS: F1 famine exposure in utero did not affect F2 (n = 1496) birthweight, but, among the offspring of famine-exposed F1 women, F2 birth length was decreased (-0.6 cm, P adjusted for F2 gender and birth order = 0.01) and F2 ponderal index was increased ( 1.2 kg/m(3), P adjusted for F2 gender and birth order = 0.001). The association remained unaltered after adjusting for possible confounders. The offspring of F1 women who were exposed to famine in utero also had poor health 1.8 (95% CI 1.1-2.7) times more frequently in later life (due to miscellaneous causes) than that of F1 unexposed women. These findings may imply that the increase in chronic disease after famine exposure in utero is not limited to the F1 generation but persists in the F2 generation. |
| Keyword(s): | birth length, famine, intergenerational studies, lung function, transgenerational |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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