Primal Health Databank: Study
| Entry No: | 0730 |
| Title: | Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study |
| Author(s): | Lumey LH, Kahn HS, Stein AD, Romijn JA |
| Reference: | Am J Clin Nutr. 2009 Jun;89(6):1737-43. |
| Place of Study: | USA |
| Abstract: | In 2003-2005, the authors studied 1) 359 singleton men and women born between January 1945 and March 1946 in clinics in Amsterdam, Rotterdam, and Leiden whose mothers were exposed to the famine during pregnancy; 2) 299 singletons born in the same 3 institutions during 1943 or 1947; and 3) 313 unexposed same-sex siblings of the above individuals. A lipid profile was obtained after an overnight fast. Female offspring with prenatal famine exposure had a dyslipidemic pattern characterized by elevated total cholesterol (0.26 mmol/L; 95% CI: 0.07, 0.46; P = 0.007), triglycerides (0.17 mmol/L; 95% CI: 0.03, 0.31; P = 0.02), and LDL cholesterol (0.17 mmol/L; 95% CI: -0.01, 0.36; P = 0.06) compared with unexposed offspring. This pattern was not seen in men. The increases in total cholesterol and LDL cholesterol were independent of body mass index, waist circumference, and midthigh circumference. The increase in triglycerides was independent of midthigh circumference but was attenuated with control for either body mass index or waist circumference. There was no evidence for associations within specific gestational windows. No association was observed between prenatal famine exposure and HDL cholesterol in either sex. CONCLUSION: In women, but not in men, aged approximately 58 y, an association was observed between prenatal undernutrition and elevated total cholesterol concentrations and triglycerides. |
| Keyword(s): | cholesterol, famine, lipid profile |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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