Primal Health Databank: Study
| Entry No: | 0725 |
| Title: | Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence |
| Author(s): | Opler MG, Buka SL, Groeger J, et al. |
| Reference: | Environ Health Perspect. 2008 Nov;116(11):1586-90. Epub 2008 Jul 30 |
| Place of Study: | USA |
| Abstract: | BACKGROUND: A previously conducted study of prenatal lead exposure and schizophrenia using delta-aminolevulinic acid, a biologic marker of Pb exposure, in archived maternal serum samples collected from subjects enrolled in the Childhood Health and Development Study (1959-1966) based in Oakland, California, suggested a possible association between prenatal Pb exposure and the development of schizophrenia in later life. OBJECTIVES: In the present study the authors extend these findings using samples collected from the New England cohort of the National Collaborative Perinatal Project (1959-1966). Using similar methods, in this study they found results that suggest a comparable association in this cohort. METHODS: The authors pooled matched sets of cases and controls from both the California and New England sites using a multilevel random-intercept logistic regression model, accounting for matching and site structure as well as adjusting for maternal age at delivery and maternal education. RESULTS: The estimated odds ratio for schizophrenia associated with exposure corresponding to 15 microg/dL of blood Pb was 1.92 (95% confidence interval, 1.05-3.87; p = 0.03). CONCLUSION: Although several limitations constrain generalizability, these results are consistent with previous findings and provide further evidence for the role of early environmental exposures in the development of adult-onset psychiatric disorders. |
| Keyword(s): | lead, schizophrenia |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search