Primal Health Databank: Study
| Entry No: | 0724 |
| Title: | Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child. |
| Author(s): | Sayers A, Tobias JH |
| Reference: | J Clin Endocrinol Metab. 2008 Dec 30. [Epub ahead of print] |
| Place of Study: | UK |
| Abstract: | Setting: The Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort. Participants: 6955 boys and girls mean age 9.9 years. Outcome measures: Pre-specified analyses of relationships between background UVB levels in the third trimester of pregnancy, and total body less head BMC, bone area (BA), bone mineral density (BMD) and area-adjusted BMC (ABMC) as measured by DXA scans at 9.9 years. Results: Maternal UVB exposure was positively related to BMC (g) [9.6 (5.3, 13.8)], BA (cm(2)) [8.1 (4.3, 11.9)] and BMD (g.cm(-2)) [0.003 (0.001, 0.004)], but not ABMC (g) [0.69 (-0.22, 1.56)], suggesting an effect on bone size. Both height-dependent (cm) [0.18 (0.03, 0.32)] and height-independent (cm(2)) [4.1, (2.0, 6.2)] effects contributed to this association between UVB and BA. Although maternal UVB exposure was also related to lean mass (g) [163 (89, 237)], a positive association between UVB and BA persisted after adjusting for both height and lean mass [2.8 (1.0, 4.6)]. Conclusions: Maternal UVB exposure is related to bone size at age 9.9 independently of height and lean mass, suggesting vitamin D status in pregnancy exerts direct effects on periosteal bone formation in subsequent childhood. |
| Keyword(s): | bone density, vitamin D |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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