Primal Health Databank: Study
| Entry No: | 0700 |
| Title: | Neonatal Thyroid Function in Seveso 25 Years after Maternal Exposure to Dioxin. |
| Author(s): | Baccarelli A, Giacomini SM, Corbetta C, et al. |
| Reference: | Plos Medicine July 2008; 5(7) |
| Place of Study: | Italy |
| Abstract: | Between 1994 and 2005, in individuals exposed to TCDD after the 1976 Seveso accident the authors conducted: (i) a residence-based population study on 1,014 children born to the 1,772 women of reproductive age in the most contaminated zones (A, very high contamination; B, high contamination), and 1,772 age-matched women from the surrounding noncontaminated area (reference); (ii) a biomarker study on 51 mother–child pairs for whom recent maternal plasma dioxin measurements were available. Neonatal blood thyroid-stimulating hormone (b-TSH) was measured on all children. They performed crude and multivariate analyses adjusting for gender, birth weight, birth order, maternal age, hospital, and type of delivery. Mean neonatal b-TSH was 0.98 μU/ml (95% confidence interval [CI] 0.90–1.08) in the reference area (n = 533), 1.35 μU/ml (95% CI 1.22–1.49) in zone B (n = 425), and 1.66 μU/ml (95% CI 1.19–2.31) in zone A (n = 56) (p < 0.001). The proportion of children with b-TSH > 5 μU/ml was 2.8% in the reference area, 4.9% in zone B, and 16.1% in zone A (p < 0.001). Neonatal b-TSH was correlated with current maternal plasma TCDD (n = 51, β = 0.47, p < 0.001) and plasma toxic equivalents of coplanar dioxin-like compounds (n = 51, β = 0.45, p = 0.005).
Conclusions
Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure.
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| Keyword(s): | dioxins, thyroid function |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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