Primal Health Databank: Study
| Entry No: | 0690 |
| Title: | Breast-feeding and type 2 diabetes in the youth of three ethnic groups: the SEARCh for diabetes in youth case-control study |
| Author(s): | Mayer-Davis EJ, Dabelea D, Lamichhane AP, D'Agostino RB Jr, Liese AD, Thomas J, McKeown RE, Hamman RF |
| Reference: | Diabetes Care. 2008 Mar;31(3):470-5 |
| Place of Study: | USA |
| Abstract: | Eighty youth with type 2 diabetes aged 10-21 years were included. Nondiabetic control participants were recruited from primary care provider offices (n = 167). Breast-feeding information was recalled by biological mothers. Prevalence (%) of breast-feeding (any duration) was lower among youth with type 2 diabetes than among control subjects (19.5 vs. 27.1 for African Americans, 50.0 vs. 83.8 for Hispanics, and 39.1 vs. 77.6 for non-Hispanic whites). The overall crude odds ratio for the association of breast-feeding (ever versus never) and type 2 diabetes was 0.26 (95% CI 0.15-0.46). Results were similar by race/ethnic group (P value for interaction = 0.17). The odds ratio for the association after adjusting for 12 potential confounders was 0.43 (0.19-0.99). When current BMI z-score was added to the model, the odds ratio was attenuated (0.82 [0.30-2.30]), suggesting possible mediation through current childhood weight status. Analyses that incorporated duration of breast-feeding, adjusted for potential confounders, provided evidence for dose response (test for trend, P value <0.0001), even after inclusion of BMI z-score. CONCLUSIONS: Breast-feeding appears to be protective against development of type 2 diabetes in youth, mediated in part by current weight status in childhood.
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| Keyword(s): | breastfeeding, diabetes type 2 |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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