Primal Health Databank: Study
| Entry No: | 0662 |
| Title: | Birth weight and the risk of testicular cancer: A meta-analysis |
| Author(s): | Michos A, Xue F, Michels KB |
| Reference: | Int J Cancer. 2007 Sep 1;121(5):1123-31 |
| Place of Study: | USA |
| Abstract: | Thirteen epidemiologic studies, published between 1983 and 2004, were included in the analysis, encompassing 5,663 patients with testicular cancer. Men weighing less than 2,500 grams at birth had a higher risk for developing testicular cancer later in life than those with normal birth weight (2,500-4,000 g) (OR = 1.18; 95% confidence interval (CI) 1.01-1.38). A similar trend was found for men with a birth weight above 4,000 g, (OR = 1.12; 95% CI 1.02-1.22). When seminoma and nonseminoma testicular cancer cases were considered separately, low birth weight was a risk factor specifically for seminomas (OR = 1.44; 95% CI 1.11-1.88). A U-shaped association was observed between birth weight and the risk for testicular cancer. The underlying biological mechanisms for this phenomenon remain to be elucidated.
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| Keyword(s): | birthweight, testicular cancer |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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